| Pair Name | Ursolic acid, Oxaliplatin | ||
| Phytochemical Name | Ursolic acid (PubChem CID: 64945 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Ursolic acid, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BIRC5 | hsa332 |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 |
| Result | These observations suggested that a combination of UA and Oxa elicited synergistically anticancer effects in RKO cells and provided new evidence for potential application of UA and Oxa for CRC treatment. | |||
| Pair Name | Ursolic acid, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Down-regulation | Expression | ABCC1 | hsa4363 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | HCT 8 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_2478 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Our study provided evidence that ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by ROS-mediated inhibition of drug resistance. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells. Pharmazie. 2020 Jun 1;75(6):246-249. doi: 10.1691/ph.2020.0417. | Click |
| 2 | Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance. Cancer Sci. 2018 Jan;109(1):94-102. doi: 10.1111/cas.13425. | Click |
